2006 Colorado P0300 and P0301 Random Misfire: What Should I Do Next?

Model: 06 Colorado Fault Code: P0300 Posted: 2010-12-24 08:19

I ran a diagnostic on my 2006 Colorado yesterday and received both the P0300 (random misfires) and P0301 (cylinder 1 misfire) codes. The truck has been exhibiting rough idle and an unstable tachometer reading. I've already replaced the spark plugs and plug boots, and recently changed the air filter as well. Now I'm wondering whether I should also replace the fuel filter. Any advice on the next steps would be greatly appreciated. Thanks for your help!